Combinostics was founded in August 2014 with the goal to develop and market advanced tools for data-driven diagnostics. The founders have unique know-how in clinical decision support with strong expertise on biomarker discovery. The technology builds on software and innovations that have been developed over many years at VTT Technical Research Centre of Finland.
Harry Brade – Chairman of the Board
Jyrki Lötjönen – Board member, Founders representative
Toni Mattila – Board member, Investor representative
Tero Weckroth – Board member, joint representative
Lennart has worked for more than twenty-five years in in development and management roles in healthcare industry. He has a PhD in medical image processing from Uppsala University (Sweden) and he holds a part-time position as professor in neuroimaging at the Institute of Neuroscience and Physiology at the University of Gothenburg (Sweden).
Jyrki has Ph.D. degrees from Helsinki University of Technology (Finland) and INSA of Lyon (France) in 2000. He is a principal scientist in the ICT for health research area at VTT Technical Research Centre of Finland, CSO at Combinostics Ltd and adjunct professor at Aalto University (Finland). His research interests are in medical image analysis, data mining and decision support systems. He has co-authored more than 100 international peer-reviewed scientific papers.
Jussi received his Ph.D. degree from Tampere University of Technology (Finland) in 2014. His has vast experience in designing and implementing clinical decision support systems and software engineering in general. He was a developer of the PredictAD software that is extended to support differential diagnostics of dementia in VPH-DARE@IT.
Juha received his Ph.D. degree from Helsinki University of Technology (Finland) in 2006. He manages image analysis development at Combinostics Ltd and he also has a position as adjunct professor in Medical image processing at University of Eastern Finland. He has extensive experience in medical image quantification and clinical decision support systems. He has co-authored over 50 international peer-reviewed papers.
Markus has an MSc, Electrical Engineering (Signal Processing) from the University of Oulu (Finland). He has more than fifteen years professional software development experience.
cNeuro is Combinostics’ suite of tools for quantitative assessment of brain images and for providing clinical decision support in neurological disorders. Our first module, cMRI, provides fully automated quantification of MR brain scans.
Combinostics’ goal is to provide tools that bring a disruptive change to clinical decision making, enabling objective and confident diagnostics in complex diseases. Combinostics’ solution combines all available information and replaces silos of data with a holistic view of the patient’s disease state. Moreover, decision support is provided by contrasting the data from an individual patient with the corresponding data from previously diagnosed patients, where outcome is known through longitudinal follow-up.
Combinostics’ technology is generic and can be applied in several disease areas but our initial focus is on clinical decision support in neurodegenerative diseases (see publications).
Our suite of tools includes fast and robust methods for extraction of imaging biomarkers. The methods have been rigorously validated and results have been published in leading scientific journals (see publications). Our main focus is on tools for MR image processing, but methods for PET and CT image analysis are also available. MR image processing tools include methods for skull stripping, fast non-linear image registration, hippocampal segmentation and segmentation of general cortical and subcortical structures. Tools for voxel-based and tensor-based morphometry are also available as well as for quantifying vascular burden.
Our imaging quantification tools are an important part of our clinical decision support system but we also provide services around integration of our tools into 3rd party products.