Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease

European Journal of Neurology

H. Jokinen, H.M. Laakso, M. Ahlström, A. Arola, J. Lempiäinen, J. Pitkänen, T. Paajanen, S.A.M. Sikkes, J. Koikkalainen, J. Lötjönen, A. Korvenoja, T. Erkinjuntti, S. Melkas

An extensive clinical, physical, neuropsychological, and MRI protocol was used to assess 152 participants of the Helsinki Small Vessel Disease Study. Automated segmentation was used to obtain volumes of white matter hyperintensity (WMH) and gray matter (GM). There were strong relationships between cognitive and motor functions as well as with instrumental activities of daily living (IADL), quality of life, WMH volumes, and GM volumes. Functional outcomes in cerebral small vessel disease (SVD) is affected by a complex interplay and synergism between motor and cognitive abilities.