Effects of white matter hyperintensities on verbal fluency in healthy older adults and MCI/AD

Frontiers in Aging Neuroscience

A. Kaskikallio, M. Karrasch, J. Koikkalainen, J. Lötjönen, J.O. Rinne, T. Tuokkola, R. Parkkola, P. Grönholm-Nyman

In this study with 42 cognitively healthy older adults and 44 adults with MCI/AD, semantic and phonemic fluency were measured, and quantified MRI imaging data were collected. Based on the results, white matter pathology in both frontal and parieto-occipital cerebral areas may be associated with impaired semantic fluency in right-handed older adults. However, elevated levels of white matter hyperintensities do not seem to be associated with cumulative effects on verbal fluency impairment in patients with MCI or AD.