Evaluating combinations of diagnostic tests to discriminate different dementia types

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

M. Bruun, H. Rhodius-Meester, J. Koikkalainen, M. Baroni, L. Gjerum, A. Lemstra, F. Barkhof, A. Remes, T. Urhemaa, A. Tolonen, D. Rueckert, M. van Gils, K. Frederiksen, G. Waldemar, P. Scheltens, P. Mecocci, H. Soininen, J. Lötjönen, S. Hasselbalch, W. van der Flier

The results from this study indicate that the accuracy of differential diagnostics for dementias might be improved by combining the results of different diagnostic tests. Using a data-driven approach, the performance accuracy of individual and combined cognitive tests, cerebrospinal fluid biomarkers, and automated MRI features for differentiating between dementia types was assessed. Patients included those with Alzheimer’s disease, frontotemporal dementia, dementia with Lewy bodies, or vascular dementia, as well as healthy controls.